The bacteria in one’s digestive tract may play a significant role in the pathogenesis of arthritis.
In a new study, mice were fed high-calorie diets in order to induce weight gain. As the mice gained weight, pro-inflammatory bacteria dominated their digestive tract. The changes in gut bacteria coincided with an increase in systemic inflammation as well as a heightened level of inflammation localized in the knee. Not surprisingly, the researchers found that in these inflammed mice, joint deterioration occurred rapidly. When the researchers induced a tear in the meniscus, the cartilage deteriorated over the course of 12 weeks.
Amazingly, when the mice were given a prebiotic supplement, the weight gain did not have the same effect on the gut microbiome. Inflammation levels did not increase as they previously had and when the meniscus was damaged, the cartilage did not deteriorate.
Conclusions
This incredible study highlights the role that gut bacteria may play in arthritis. By increasing inflammation levels, gut bacteria may directly influence cartilage metabolism and joint degeneration. Those who wish to prevent or treat arthritis may benefit from maintaining a healthy weight and taking steps to ensure a healthy gut microbiome.
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